Graduate student Amy Siebert has paper featured in Global Medical Discovery

Global Medical Discovery is a publication that highlights landmark papers in science and medicine. Their advisory team selects only a handful of the very best papers out of over 20,000 published weekly. This week, Global Medical Discover is featuring an OU paper that was discussed here in the CBR News previously. Graduate student Amy Siebert published “Effects of estrogen metabolite 2-methoxyestradiol on tumor suppressor protein p53 and proliferation of breast cancer cells” in the journal Systems Biology in Reproductive Medicine last fall (Volume 57, Pages 279-287, 2011). Coauthors are graduate student Amy Sanchez, Assistant Professor Sumi Dinda of the School of Health Sciences, and former Professor Virinder Moudgil. The Global Medical Discovery also publishes additional information that helps to put the paper into context:

“Although relationship between steroid hormones and breast cancer had been widely known and published over the last few decades, our laboratory initially demonstrated hormonal regulation of the p53 tumor suppressor protein in T47D human breast carcinoma cell line (Hurd, C. et al, J. Biol. Chem. 270 (1995) 28507-28510). The results of this study showed that estradiol stimulates p53 to regulate proliferation of T47D cells in culture. Our laboratory further showed for the first time an estradiol receptor-mediated mechanism for coordinate expression of two tumor suppressors (p53 and hyperphosphorylation of retinoblastoma) during estradiol-induced proliferation of T47D cancer cells (Hurd et al., Oncogene 15 (1997) 991-995). The recent paper on effects of estrogen metabolite on p53 extends our earlier observations on the relationship between steroid hormones, the tumor suppressors and proliferation of T47D cancer cells. The observation that an estradiol metabolite significantly inhibits the rate of proliferation of breast cancer cells has potential implications in elucidating the mechanism of hormone action as well as steroid regulation of growth of cancer cells.”