"Pulmonary damage after radiotherapy is typically characterized by an
initial alveolar inflammation (pneumonitis) followed by chronic
fibrosis. In the present study, changes in lung architecture were
measured in the pneumonitis phase after whole-body low-dose X irradiation of C57BL/6 mice. Radiation damage was evaluated at 24 h and
1-8 weeks postirradiation. Three distinct scoring systems were used:
(1) manually evaluating alveolar distortion and infiltration of
inflammatory cells into the alveolar space using a continuous numerical
scale across an entire lung section, (2) physically measuring the
average thickness of the alveolar septa from multiple representative
microscope fields, and (3) a new rapid automated mathematical algorithm
based on image segmentation of alveolar space across an entire section.
Each scoring method detected significant changes in alveolar
architecture at the earliest times compared with sham-treated controls
and gave comparable evaluations of injury. The results from the
automated mathematical algorithm correlated significantly with both the
manual evaluation method (Spearman's correlation coefficient rho =
0.044) and the direct physical measurement of septa thickness (rho =
0.002). These data demonstrate that evaluating alveolar space by
segmentation analysis provides a reliable method for scoring early
pulmonary radiation damage that is consistent with more established
methodologies but is more rapid and is independent of potential
operator and selection bias."
Assistant Professor Jia Li, of the Electrical and Computer Engineering Department, and a team of Beaumont Hospital researchers study how the lungs respond to x rays.
Created by Brad Roth (firstname.lastname@example.org) on Sunday, April 25, 2010 Modified by Brad Roth (email@example.com) on Sunday, April 25, 2010 Article Start Date: Sunday, April 25, 2010