Distinguished Professor Mike Chopp Investigates Stroke

Distinguished Professor Michael Chopp, of the Department of Physics, and his colleagues at Henry Ford Hospital are leaders in the study of stroke. In the January 2009 issue of the Journal of Neuroscience Research Chopp's team published Nitric Oxide Donor Up-Regulation of SDF1/CXCR4 and Ang1/Tie2 Promotes Neuroblast Cell Migration After Stroke (Volume 87, Pages 86-95). Nitric Oxide is a small molecule with such a big role in biology and medicine that Science Magazine named it the 1992 Molecule of the Year. Chopp et al. "tested the hypothesis that a nitric oxide donor, DETA-NONOate, up-regulates stromal cell-derived factor-1 and angiopoietin 1 in the ischemic brain and their respective receptors chemokine CXC motif receptor 4 and Tie2 in the subventricular zone and thereby promote...neuroblast cell migration after stroke." Their work is supported by grants from the National Institutes of Health and the American Heart Association.